李小卫
博士,副研究员,硕士生导师。漫画同人 -尼康(仪器)超分辨成像联合实验室负责人。本科毕业于武汉大学物理系;硕士毕业于中国科学院上海微系统与信息技术研究所;博士毕业于美国弗吉尼亚大学电子与计算机工程系。长期从事多学科交叉的研究工作,建立了具有特色的3D空间生物(组)学技术体系,部分研究成果已经成功产业化,在基础生命科学研究、药物开发和临床精准诊断方面具有重要的潜在应用价值。发表学术文章40余篇,申请专利34项(已授权15项,两项PCT专利)。主持和参与多项国家和省部级科研项目,包括国家自然科学基金,国家重大科研仪器研制项目,上海市科委纳米技术专项等。
|
基金 |
名称 |
项目编号 |
项目时间 |
担任角色 |
|
国家自然科学基金青年基金项目 |
太赫兹光谱检测人染色体端粒DNA空间构象关键技术研究 |
60907044 |
2010.1-2012.12 |
负责人 |
|
上海市科学技术委员会纳米技术专项 |
应用于单个蛋白大分子的非接触原子力显微镜仪器表征方法、成像机制和高分辨技术研究 |
1052nm07700 |
2010.3-2012.6 |
骨干 |
|
上海市浦江人才计划项目 |
多细胞生物DNA复制起点的单分子研究 |
10PJ1405100 |
2010.7-2012.6 |
骨干 |
|
国家自然科学基金重大研究计划培养项目 |
新型合成m-PE刚性分子大环自组装形成可控疏水纳米孔的机理研究 |
91027020 |
2011.1-2013.12 |
骨干 |
|
漫画同人 “医工(理)交叉研究基金”重点项目 |
基于完整肿瘤组织单细胞分辨率3D空间成像技术实现肿瘤病人个体化诊疗 |
YG2021ZD08 |
2022.1-2025.12 |
负责人 |
|
|
|
1. Cao, X., et al., Light-Sheet Microscopic Imaging of Whole-Mouse Vascular Network with Fluorescent Microsphere Perfusion. ACS Biomaterials Science & Engineering, 2024. 10(9): p. 5609-5616.
2. Liu, Z., et al., Structural and functional imaging of brains. Science China Chemistry, 2023. 66(2): p. 324-366.
3. Zhang, Y., et al., Imaging of fluorescent polymer dots in relation to channels and immune cells in the lymphatic system. Materials Today Bio, 2022. 15: p. 100317.
4. Zhang, X., et al., Robust acquisition of spatial transcriptional programs in tissues with immunofluorescence-guided laser capture microdissection. Frontiers in Cell and Developmental Biology, 2022. 10: p. 853188.
5. Nie, Y., et al., Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM. Cell Biology and Toxicology, 2022. 38(6): p. 1175-1197.
6. Li, Q., et al., Ischemia preconditioning alleviates ischemia/reperfusion injury-induced coronary no-reflow and contraction of microvascular pericytes in rats. Microvascular research, 2022. 142: p. 104349.
7. Li, J., et al., Spatiotemporal quantification of metastatic tumour cell growth and distribution in lymph nodes by whole-mount tissue 3D imaging. International journal of biological sciences, 2022. 18(10): p. 3993.
8. Feng, Y., et al., The brain as a structure: A model of how fluid–structure interactions stiffen brain tissue after injury. Engineering Structures, 2022. 256: p. 113960.
9. Zhang, N., et al., Efficient and fast immuno-labeling of clarified tissues using low-field enhanced diffusion. IEEE Transactions on Biomedical Engineering, 2021. 68(11): p. 3301-3307.
10. Wu, C., et al., Whole-mount kidney clearing and visualization reveal renal sympathetic hyperinnervation in heart failure mice. Frontiers in Physiology, 2021. 12: p. 696286.
11. Wang, W., et al., Three‐dimensional quantitative imaging of native microbiota distribution in the gut. Angewandte Chemie International Edition, 2021. 60(6): p. 3055-3061.
12. Bao, Z., et al., Ratiometric Raman nanotags enable intraoperative detection of metastatic sentinel lymph node. Biomaterials, 2021. 276: p. 121070.
13. Li, J., et al., Fast immuno-labeling by electrophoretically driven infiltration for intact tissue imaging. Scientific reports, 2015. 5(1): p. 10640.
邮箱地址:[email protected]
联系电话:86-21-34207341
办公地址:闵行校区文选医学楼126室